Copyright © 2012 Türk İkizler

## Fazil Aliev, Ph.D.

Virginia Commonwealth University,

Virginia Institute for Psychiatric and Behavior Genetics,

School of Medicine, Department of Psychiatry

Phone: (804)828-8745

E-mail: faliev@vcu.edu

**Personal:** US Citizen.

**Education:**

**1989. Ph.D. in ** Probability Theory and Mathematical Statistics, Lomonosov Moscow State University, Faculty of Computational Mathematics and Cybernetics, Department of Mathematical Statistics, Moscow, Russia.
**Thesis:** Upper and Lover Estimates of the Rate of Convergence in the Central Limit Theorem in Hilbert Space. **Advisor:** Professor V. Sazonov, Steklov Mathematical Institute, Russian Academy of Sciences.

**1985. M.S. and B.S. in** Applied Mathematics, Lomonosov Moscow State University, Faculty
of Computational Mathematics and Cybernetics, Department of Mathematical. Statistics, Moscow, Russia.

**Employment:**

**2009-present** Research Associate, Virginia Commonwealth University, Departments of Psychiatry, Statistical Science and Operational Research. Richmond VA.

**2007-2009** Postdoctoral Researcher, Virginia Commonwealth University, School of Medicine. Richmond VA.

**2005-2008** Postdoctoral Researcher, Washington University in St. Louis, School of Medicine. Department of Psychiatry,

**2004-2007** Associate Professor, Department of Statistics and Institute of Biotechnology,
Ankara University, Ankara, Turkey (partly on sabbatical leave)

**1999-2004** Associate Professor and Vice-Chair, Department of Industrial Engineering, Baskent University, Ankara, Turkey.

**1995-1999** Visiting Associate Professor, Department of Statistics, Ankara University, Turkey.

**1994-2005** Senior Programmer, Zirve Computer Company, Ankara, Turkey.

**1989-1995** Associate Professor, Department of Applied Mathematics, Baku State University, Baku, Azerbaijan.

**1985-1989** Scientific Researcher-Computer Programmer - Geological Department, Moscow State University, Moscow, Russia.

**Research Interests:**

**Subject of the scientific works:** Biostatistics, Genetics, Psychiatry, Some Problems of the Theory of Probability and Mathematical Statistics. Order Statistics, Records,
Limit Theorems and Distribution Theory, Mathematical Modeling in Geology and Chemical Engineering.

I am working with my students and colleagues on extreme value problems (order statistics, records and characterizations), control theory problems and some engineering problems.

In addition, the last seven years my research is mainly concentrated on identifying genes involved in human IQ and different psychiatric disorders. I’m working on the Collaborative Study on the Genetics of Alcoholism (COGA), the Finnish Twin Studies (Finn Twin12, Finn Twin16), the Irish Affected Sibling Pair Study of Alcohol Dependence (IASPSAD), Avon Longitudinal Study of Parents and Children (ALSPAC) projects and some other projects of Human Genetics groups as Research Associate faculty member. I am involved in all stages of data analyses including methodological studies, data cleaning and preparation using the data from different sources. Multiple testing problems, nonparametric testing problems and estimation of their power are part of problems I am working on in parallel to genetics research. I’ve developed and working on the software which collects only necessary data from different GWAS analyses outputs and creates compact resulting files depending on selected options. This software runs several times Plink, Haploview, Excel and Visual Basic Applications on background depending on options.

Database programming is one of my hobbies for last 20 years.

**Computer skills:**

1. Statistical packages: SPSS (with coding), MINITAB, SAS (with macros), STATA, R (including user interfaces) for processing different forms of data and analyses.

2. MS Office programs.

3. I’ve created a program running automatically Plink association analyses with SNPs from different studies to check replications with COGA GWAS data and creating a resulting Excel file with full information (LD, significant p-values, permutation results, HWE and MAF information).

4. SQL servers: MS SQL, MySQL (with stored procedures, triggers).

5. Approximately 20 years of Visual Foxpro database design experience (all versions up to 9.0, preceded with Clipper, Foxbase, Dbase, Arago). As a senior programmer of Zirve Ltd. I developed the software “Icrapro” for law companies which covers all basic needs of lawyers in screening, reporting, financial calculations, creating different types of forms and etc. for Court case records.

6. I used Visual Basic, Fortran and Matlab for some technical and mathematical problems.

7. I use Perl for data manipulation and have an experience of Php and Java(with MySQL applications) programming.

**Publications:** Referred journals > 35; Proceedings > 20; Oral and poster presentations >20.

**Languages:** English, Russian, Turkish, Azeri.

**Professional activities:**

**Courses taught:**

*Undergraduate level:* Probability Theory, Statistical Analysis, Stochastic Models, Discrete Mathematics, Queuing Theory, Analytical Geometry, Mathematical Analysis.

*Graduate level:* Statistics in Genetics, Statistical Analysis (mathematical theory of statistics), Reliability Theory, Measure Theory, Limit Theorems, Stochastic Processes, Cryptology, Statistical Computing
with R.

**Advisorship:** Ph.D-1, M.S.-7.

**Associate Editorships:**

*Journal of Statistical Theory and Applications,* Ed.: Prof. M. Ahsanullah, Rider University, USA,

*Istatistik, Journal of Turkish Statistical Society,* Ed.: Prof. O. L. Gebizlioglu, Ankara Univ., Turkey.

**Reviewer:** Mathematical Reviews; IEEE Transactions on Automatic Control, Metron, Journal of Applied Statistical Science,
Mathematical Problems in Engineering, Journal of Statistical Theory and Applications, Statistics and Probability Letters, Statistical Papers,
Neuropsychiatric Genetics and several others.

**Awards and memberships:**

1. International Society of Psychiatric Genetics, 2009 Alcohol Travel Award.

2. Behavior Genetics Association, Fulker Award for the Best Paper published in 2007 (second author).

3. Member, Behavior Genetics Association, 2005-

4. National Institutes of Health, NIMH, Postdoctoral Fellowship, 2005-2008.

5. NATO Advanced Study Institute Fellowship, Stanford University, 2003.

6. NATO Advanced Study Institute Fellowship, SUNI at Stony Brook, 1999.

7. NATO Research Fellowships, 1995-1998.

**Workshops:**

1. NATO Advanced Study Institute: Stochastic Games and Applications, SUNY, Stony Brook, 1999,

2. 9th International Workshop on Virus Evolution and Molecular Epidemiology, Stanford University, June, 2003,

3. International Workshop on Methodology of Twin and Family Studies, University of Colorado, Boulder, March, 2005,

4. International Workshop on Methodology of Twin and Family Studies, University of Colorado, Boulder, March, 2006,

5. Linkage and Association Workshop, Egmond aan Zee, The Netherlands, September, 2007,

6. The 22nd International Statistical Genetics Methods Workshop, Leuven, Belgium, August, 2008.

**References:**

Dr. Danielle Dick, VCU, Virginia Institute for Psychiatric and Behavior Genetics (ddick@vcu.edu)

Dr. Silviu-Alin Bacanu,VCU, Virginia Institute for Psychiatric and Behavior Genetics (sabacanu@vcu.edu)

Dr. Amrakh Mamedov, Kansas State University (am03@ksu.edu) (Manhattan, KS),

Dr. Mohammad Ahsanullah, Rider University (ahsan@rider.edu) (Lawrenceville, NJ, USA),

Dr. Vladimir Ulyanov, Moscow State University (vulyan@gmail.com) (Moscow, Russia),

**Publications:**

**Peer reviewed journal papers:**

Derringer J., Krueger R.F., Dick D.M., **Aliev F.**, et al. (2012) The Aggregate Effect of Dopamine Genes on
Dependence Symptoms Among Cocaine Users: Cross-Validation of a Candidate System Scoring Approach, Behavior Genetics, accepted.

Edwards A.C., **Aliev F.**, et al. (2011). Genome-wide association study of comorbid depression and
alcohol dependence. Psychiatric Genetics, 21(1),31-41.

Kendler K.S., Kalsi G., Holmans P., Sanders A.R., M.D.4, Aggen S.H., Dick D.M., **Aliev F.**, Levinson D.F., Gejman P.V., (2010).
Genomwide Association Analysis of Symptoms of Alcohol Dependence in the MGS Control Sample, Alcohol Clin Exp Res., 35(5): 963-975.

Schumann G., Coin L.J., Lourdusamy A., Charoen P., Berger K.H., Stacey D., Desrivieres S., **Aliev F.** et al. (2011).
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in
the regulation of alcohol consumption, Proc Natl Acad Sci U S A., 108(17):7119-7124.

Ahsanullah M., **Aliev F.** (2011). Characterization of Geometric Distribution Based on Weak Records,
Statistical Papers, 52(3), 651-655.

Oncel S.Y., Gebizlioglu O.L. and **Aliev F.** (2011). Risk factors of the smoking behavior among university students, Turkish Journal of Health Sciences, accepted. DOI:10.3906/sag-1009-1122.

Maher B.S., Vladimirov V.I., Latendresse S.J., Thiselton D.L., McNamee R., Kang M., Bigdeli T.B., Chen X., Riley B.P., Hettema J.M., Chilcoat H., Heidbreder C., Muglia P., Murrelle E.L.,
Dick D.M., **Aliev F.** et al. (2011). The AVPR1A gene and Substance Use Disorders: Association, Replication and Functional Evidence, Biological Psychiatry,70(6): 519-527.

Dick D.M., **Aliev F.**, et al. (2010). Rutgers Alcohol Problem Index Scores at Age 18 Predict Alcohol
Dependence Diagnoses Seven Years Later, Alcohol Clin Exp Res., 35(5): 1011-1014.

Hack L.M., Kalsi G., **Aliev F.**, Kuo P.H., Prescott C.A., Patterson D.G., Walsh D., Dick D.M., Riley
B.P., Kendler K.S. (2010). Limited Associations of Dopamine System Genes with Alcohol Dependence and Related Traits in the Irish Affected Sib Pair Study of
Alcohol Dependence (IASPSAD), Alcohol Clin Exp Res., 35(2):376-85.

Dick D.M., **Aliev F.** et al. (2010). Genome Wide Association Study (GWAS) of Conduct Disorder Symptomatology, Molecular Psychiatry, accepted. DOI:10.1038/mp.2010.73.

Dick D.M., Meyers J., **Aliev F.** et al. (2010). Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts, Am J Med Genet B Neuropsychiatr Genet, 153B(6):1179-1188.

Kalsi G., Kuo P.H., **Aliev F.** et al. (2010). A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Hum Mol Genet. 2010 Jun 15; 19(12):2497-506. Epub 2010 Mar 23.PMID: 20332099.

Edenberg H.J., Koller D.L., Xuei X., Wetherill L., McClintick J.N., Almasy L., Bierut L.J., Bucholz K.K., Goate A., **Aliev F.** et al. (2010). Genome-wide association study of alcohol dependence implicates a region
on chromosome 11. Alcohol Clin Exp Res. 2010 May; 34(5):840-52. Epub 2010 Mar 1.PMID: 20201924.

Dick D.M., Bernard M.C., **Aliev F.** et al. (2009). The Role of Socioregional Factors in Moderating Genetic Influences on Early Adolescent Behavior Problems and Alcohol Use, Alcohol. Clin. Exp. Res. 33(10): 1739-48.

Ahsanullah M., **Aliev F.** (2008). Some Characterizations of Exponential Distribution by Record Values, Journal of Statistical Research, 2(42), 41-46.

Dick D.M., **Aliev F.**, Wang J.C. et al. (2008). A Systematic SNP Screen to Fine-Map Alcohol Dependence Genes on Chr 7 Identifies Association with a Novel Susceptibility Gene ACN9, Biological Psychiatry, 63(11)1047-1053.

Dick D.M., **Aliev F.**, et al. (2008). Using Dimensional Models of Externalizing Psychopathology to Aid in Gene Identification, Archives of General Psychiatry: 65(3) 310-318.

Dick D.M., Wang J.C., Plunkett J., **Aliev F.** et al.(2007). Family-Based Association Analyses of Alcohol Dependence Phenotypes across DRD2 and Neighboring Gene ANKK1, Alcohol. Clin. Exp. Res. 31(10): 1645-53.

Dick D.M., **Aliev F.**, Kramer J. et al. (2007). Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence. Behavior Genetics, 37(2) 265-272.

Zeybek Z., Cetinkaya S.Y., **Aliev F.A.**, Alpbaz M., (2007). Determination of Optimum Operating Conditions for Industrial Dye Wastewater Treatment Using Adaptive Heuristic Criticism pH Control Control, Journal of Environmental Management, 85(2), 404-414.

Altinten A., Erdogan S., Hapoglu H., **Aliev F.A.** and Alpbaz M. (2006). Application of Adaptive PID Control with Genetic Algorithm to a Polymerization Reactor at Constant Set Point. Chemical Engineering Research & Design, 84(A11): 1012-1018.

Dick D.M., **Aliev F.**, Bierut L. et al. (2006). Linkage Analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) Sample. Behavior Genetics, 36(1): 77-86.

Oncel S.Y., Ahsanullah M., **Aliev F.A.**, Aygun F. (2005). Switching record and order statistics via random contractions. Statistics and Probability Letters, 73(3): 207-217.

**Aliev F.A.** (2004). On characterizations of continuous distributions through order statistics Journal of Applied Statistical Science, 13(2): 117-122.

Altinten A., Erdogan S., **Aliev F.A.**, Hapoglu H., and Alpbaz M. (2004). Application of Adaptive PID Control with Genetic Algorithm to a Polymerization Reactor. Chemical Engineering Communications, 191(9): 1158-1172.

**Aliev F.A.** (2003). A Comment on ‘Unimodality of the Distribution of Record Statistics’, Statistics and Probability Letters , 64: 39-40.

**Aliev F.A.**, Ahsanullah M. (2002). On characterizations of discrete distributions through regressions of record values. Pakistan Journal of Statistics, V. 18(3): 415-421.

Oncel S.Y., Ahsanullah M., Gebizlioglu O.L. and **Aliev F.A.** (2001). On characterizations of Geometric distribution through normal and weak record values. J. Stoch. Modelling and Appl., 4:.53-58.

**Aliev F.A.** (2000). New characterization of discrete distributions through weak records. J. Theory Probability and Its Applications, 44(4): 756-761.

**Aliev F.A.**, Ozbek L. (1999). Evaluation of convergence rate in the central limit theorem for Kalman filter. J. IEEE Transactions of Automatic Control, 44(10): 1905-1908.

**Aliev F.A.** (1999). Characterization of Poisson distribution through weak records. in Applied Statistical Science IV, Nowa Science Publ..

Ozbek L., **Aliev F.A.** (1998). Comment on “Adaptive fading Kalman filtering”. Automatica , 34(12): 1663-1664.

Bairamov I.G., **Aliev F.A.** (1998). On the characterization of distributions through order statistics and record values. Journal of Applied Statistical Science, 7(4).

**Aliev F.A.** (1998). Characterization of geometric distribution through weak records. İstatistik, Journal of Turkish Statistical Association, 1(2): 59-66.

**Aliev F.A.** (1998). Characterization of discrete distributions through weak records. Journal of Applied Statistical Science, 8(1): 13-16.

Alpbaz M., Zeybek Z., Özbek L., **Aliev F.** (1997). A fuzzy model based control of well mixed reactor with cooling jacket., J. Lecture Notes In Computer Sciences , Springer N. 1226 p. 546.

**Aliev F.A.** (1989). On the rate of convergence in the Central Limit Theorem in Hilbert Space.- J. Theory Prob. and Its Applications, Vol. 34, No. 2, 407-409.

Gorbachev Ju.I., **Aliev F.A.**, Roslov A.G. (1988). Automatic binding of samples for depths. Moscow UniversityVestnik, Ser. 4, Geology, No.5, 54-61.

**Aliev F.A.** (1986). Lover estimate of the rate of convergence in the Central Limit theorem in Hilbert Space.-J. Theory Prob. and Its Applications, 31(4), pp. 825-828.

**Proceedings, book chapters and conference abstracts:**

**Aliev F.**, Ozturk M, Edenberg H. et al. (2009). Genomewide Association Study of Externalizing disorders, XVII World Congress on Psychiatric Genetics (WCPG) Nov. 4–8, San Diego, CA.

Meyers J., Dick D.M., **Aliev F.**, et al. (2009). Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts, Behavior Genetics, 39(6), 670-671.

Oncel S.Y., **Aliev F.**, Dick D., et al. (2009). Fagerstrom Test for Nicotine Dependence (FTND) and smoking behavior among Turkish college students, Behavior Genetics, 39(6), 673-673.

Yan J. **Aliev F.**, Kendler K.S., et al. (2009). Investigating GxE contributions to the relationship between church attendance and alcohol dependence, Behavior Genetics, 39(6), 692-693.

Mamedov A.I., Levy G.J, **Aliev F.**, Wagner L.E. and Fox F. (2009). High energy moisture characteristics: linking between soil physical processes and structure stability. ASA-CSSA-SSSA International Annual Meeting, November 1-5, Pittsburgh, PA.

Riley B.P., Dick D.M., Kalsi G., **Aliev F.** et al. (2009). Identifying Genetic Influences on Alcohol Dependence and Related Traits in the Irish Affected Sib-Pair Study of Alcohol Dependence, Alcohol. Clin. Exp. Res. 33(6): Sp. Iss. S1. 271A.

**Aliev F.**, Dick D.M., Viken R.J. et al. (2008). Selection on Rutgers Alcohol Problem Index (RAPI) Scores in Adolescence Predicts High Rates of Alcohol Dependence in Young Adulthood, Behavior Genetics, 38(6): 613.

**Aliev F.**, Dick D.M., Kalsi G., et al. (2008). Identification of multiple genes associated with alcohol use and comorbid phenotypes on 4Q in the Irish Affected Sib-Pair Study of Alcohol dependence, Alcoholism-Clinical and Experimental Research, 32(6): 141A.

**Aliev F.A.**, (2008). On Characterizations Contınuous Distributions Through Order Statıstıcs. in New Developments in Applied Statistical Research, Ed. M. Ahsanullah, Nova Science Publishers.

Kalsi G., Kuo P.-H., Alexander J., **Aliev F.**, et al. (2008). Identification of novel candidate genes on 4Q22-Q32 in the Irish affected Sib-Pair Study of Alcohol Dependence, Alcoholism-Clinical and Experimental Research, 32(6): 143A.

Dick D.M., **Aliev F.**, Saccone S. et al. (2007). A Systematic SNP Screen to Fine-Map Alcohol Dependence Genes onChromosome 7 in COGA Sample, Behavior Genetics, 37(6): 748.

Dick D.M., **Aliev F.**, Saccone S. et al.(2007). A Systematic SNP Screen to Fine-Map Alcohol Dependence Genes on Chromosome 7 in the Collaborative Study of Genetics of Alcoholism Sample, Alcohol. Clin. Exp. Res. 31(6): 69A-69A.

**Aliev F.**, Kramer J. et al. (2006). Association of CHRM2 with IQ, Behavior Genetics, 36 (6): 952-953.

Dick D.M., **Aliev F.**, Hinrichs A. et al. (2006). Joint Analyses of Alcohol Dependence, Illicit Drug Dependence, Conduct Disorder and Antisocial Personality
in the Collaborative Study on the Genetics of Alcoholism (COGA) Sample, Alcoholism-Clinical and Experimental Research, 30 (6): 7A.

Dick D.M., **Aliev F.**, Bierut L., Wang J.C. et al. (2006). Evidence for Genes Influincing General Externalizing Psychopathology, Behavior Genetics, 36(6): 961-962.

**Aliev F.**, Bierut L., Goate A. et al. (2005). Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample. Behavior Genetics, 35(6): 793-794.

**Aliev F.**, Dick D.M., Bierut L. et al. (2005). Linkage analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Amer. J. Med. Genetics-Part B-Neuropsych. Genetics, 138B(1): 101-102.

**Aliev F.A.** (2003). Goodness of fit test based on order statistics, International Conference on Reliability and Survival Analysis, University of South Carolina, USA.

**Aliev F.A.** (2001). Characterization of geometric distributions through weak records, In: Asymptotic Methods in Probability and Statistics with Applications. Editors: N. Balakrishnan, I. A. Ibragimov, V. B. Nevzorov, Birkhauser.

**Aliev F.A.** (2001). Asymptotic distributions, new test procedures for non-classical cases and applications, Proc. of the Intl. Conf. on Mathematical and Engineering Techniques in Medicine and Biological Sciences (METMBS’2001),
Las Vegas, Nevada, , pp. 103-104.

Gebizlioglu, O.L., **Alioglu, F.A.**, Oncel, Y.S. (2001). Estimation of spatial dependence in image restoration.Proc. Inaugural Euro Conference of the Eastern Mediterranean Region of the Biometric Society, January 7-10.

**Aliev F.A.** (2000). Characterization of discrete distributions through record values. Proceedings of the International Conference on Statistics in the 21st Century, Orono, Maine, USA.

Hapoglu H., Altinten A., **Aliev F.**, Erdogan S. and Alpbaz M. (2000). Application of generalized minimum variance control with genetic algorithm to a tubular flow reactor. Proc. Of the
European Symp. on Computer Aided Process Engineering-10, pp.103-108, Florence, Italy.

**Aliev F.A.** (1999). Characterization of Poisson distribution through weak records. in Applied Statistical Science IV, Nowa Science Publ..

Zeybek Z., Alpbaz M., **Aliev F.A.** (1998). Control of nonlinear chemical reactors by a self organizing fuzzy control based on fuzzy relational matrix. Proceedings
of International symposium on intelligent Manufacturing systems IMS’98, Sakarya University, Turkey.

**Aliev F.A.** (1998). On characterization of discrete distributions through weak records. Proceedings of the Intl. Symp. Asymptotic Methods in Probability and Stat., St. Petersburg, Russia.

Gebizlioglu O.L., **Aliev F.A.** (1997). On the robust estimation for discrete space spatial processes. Proceedings of International workshop on matrix methods in statistics, Istanbul.

Bairamov I.G., **Aliev F.A.**, Gebizlioglu O.L. (1997). On the characterization of distributions through order statistics. Proc. of the 28 th Annual Iranian Mathematics Conference, Tabriz.

**Aliev F.A.** (1997). On large deviations in Hilbert Space. Proceedings of the 51 st session of the International Statistical Institute, Istanbul.

**Aliev F.A.** (1995). Convergence rates for moments of normed sums in Hilbert space. Proceedings of Research Symposium , DIE, Ankara, pp. 36-38.

**Aliev F.A.** (1988). Upper and Lover estimates of the rate of convergence in the Central Limit theorem in Hilbert Space.-Doct. Diss, Moscow University.

**Aliev F.A.** (1988). Upper and Lover estimates of the rate of convergence in the Central Limit theorem in Hilbert Space.- Autoreferat of Ph. D. Thesis, Moscow.